Topical Spray
Topical Spray
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Liposomal Topical Spray

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Key Technology Benefits

  1. Advanced Local Delivery
    • Liposomal topical sprays that combine phospholipid-based encapsulation with convenient spray administration for localized pharmaceutical delivery.
    • The liposomal carrier can enhance drug dispersion, protect sensitive actives, and support controlled interaction with the skin surface.
  2. Formulation Development
    • Based on the API’s physicochemical properties, therapeutic indication, dose, and target skin site, multiple prototype formulations are screened.
    • Key variables include phospholipid composition, lipid-to-drug ratio, vesicle characteristics, solvent system, penetration enhancers, viscosity, pH, and spray-ability.
    • Formulations can be optimized for aqueous or hydroalcoholic systems according to API compatibility and product requirements.
  3. The Science of Liposomal Topical Spray
    • Localized Pain Management: Liposomal encapsulation supports efficient deposition of the active ingredient at the application site for targeted topical action.
    • Anti-Inflammatory Effect: The formulation can facilitate localized delivery of suitable APIs to help address inflammation, swelling, and discomfort.
  4. Skin Delivery Optimization
    • The formulation is designed to promote uniform deposition and effective topical delivery while minimizing unnecessary systemic exposure.
    • Liposomal encapsulation may improve wetting, residence time, and interaction with the stratum corneum, depending on the active ingredient and vesicle design.
  5. Spray System Selection
    • Appropriate pump-spray or aerosol technology is evaluated for dose uniformity, plume characteristics, droplet size, priming, actuation force, and container compatibility.
    • Device selection is aligned with formulation rheology and intended application area to achieve consistent dosing.
  6. Analytical & Performance Evaluation
    • Development includes particle size, PDI, zeta potential, entrapment efficiency, pH, viscosity, assay, impurities, and physical stability assessment.
    • In-vitro release and ex-vivo skin permeation studies can be performed to characterize drug release, deposition, and penetration behaviour of the skin.